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Elsevier, Psychiatry Research, 2-3(133), p. 277-280
DOI: 10.1016/j.psychres.2004.10.009
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Lack of extrapyramidal side effects predicts quality of life in outpatients treated with clozapine or with typical antipsychotics
Journal article published in 2005 by
Sergio A. Strejilevich,
Ana Palatnik,
Rubén Avila,
Julián Bustin,
Julieta Cassone,
Gabriel A. de Erausquin 
,
Soledad Figueroa,
Mariana Gimenez,
G. A. De Erausquin
,
Soledad Figueroa,
Mariana Gimenez,
G. A. De Erausquin
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Abstract
We compared symptom severity and quality of life (QOL) in schizophrenic patients adequately treated with typical antipsychotics (TAP) or clozapine (CZP). Groups did not differ in symptom severity or QOL. Clozapine caused fewer extrapyramidal symptoms. Negative and extrapyramidal symptoms predicted QOL. Similar outcome in both groups suggests a common ceiling to antipsychotic efficacy.