Published in
BioMed Central, BMC Surgery, S1(12), 2012
DOI: 10.1186/1471-2482-12-s1-s15
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- [www.ncbi.nlm.nih.gov] | PDF
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Use of statins in lower extremity artery disease: a review
,
Linda Brevetti,
Anna Sannino,
Gabriele Giacomo Schiattarella,
Federica Serino,
Andreina Carbone,
Fernando Scudiero,
Marco Ferrone,
Roberto Corrado,
Raffaele Izzo ,
Lorenzo Chiariotti,
Cinzia Perrino ,
Bruno Amato,
Bruno Trimarco
and other authors.
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Abstract
Abstract Background Lower extremity artery disease (LE-PAD) is one of the most common manifestations of atherosclerosis, particularly in elderly patients, and it is related to a high cardiovascular risk. Description It is well established that statin therapy is characterized by crucial benefits on cardiovascular system by limiting atherosclerotic progression and reducing cardiovascular events and mortality. A growing body of evidence support efficacy of statins in LE-PAD due to the ability of both reducing cardiovascular risk and improving walking distance and, hence, quality of life. Consequently, statin therapy should be considered in all LE-PAD patients and new LDL-cholesterol targets should be reached. Conclusions Our opinion is that statin therapy remains still underutilized or with inadequate dosage, so therapy of LE-PAD patients should be improved to obtain all the demonstrated benefits of statins.