Published in
EDP Sciences, EPJ Web of Conferences, (83), p. 02011, 2015
DOI: 10.1051/epjconf/20158302011
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Encapsulation of paclitaxel into a bio-nanocomposite. A study combining inelastic neutron scattering to thermal analysis and infrared spectroscopy
,
Andrea Orecchini,
Luis Aguilera,
Juergen Eckert,
Jan Embs,
B. Frick,
Aleksander Matic,
M. M. Koza,
Margarida Juri Saeki,
M. Boehm,
Heloisa N. Bordallo ,
H. Mutka
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Abstract
The anticancer drug paclitaxel was encapsulated into a bio-nanocomposite formed by magnetic nanoparticles, chitosan and apatite. The aim of this drug carrier is to provide a new perspective against breast cancer. The dynamics of the pure and encapsulated drug were investigated in order to verify possible molecular changes caused by the encapsulation, as well as to follow which interactions may occur between paclitaxel and the composite. Fourier transformed infrared spectroscopy, thermal analysis, inelastic and quasi-elastic neutron scattering experiments were performed. These very preliminary results suggest the successful encapsulation of the drug.