Dissemin is shutting down on January 1st, 2025

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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 8(59), p. 5018-5021, 2015

DOI: 10.1128/aac.00052-15

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In VitroandIn VivoEfficacy of Amphotericin B Combined with Posaconazole against Experimental Disseminated Sporotrichosis

Journal article published in 2015 by Débora Nunes Mario, Josep Guarro ORCID, Janio Morais Santurio, Sydney Hartz Alves, Javier Capilla
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT We evaluated the combination of posaconazole with amphotericin B in vitro and in a murine model of systemic infections caused by Sporothrix brasiliensis and Sporothrix schenckii sensu stricto . In vitro data demonstrated a synergistic effect, and although posaconazole alone was effective against sporotrichosis, efficacy in terms of survival and burden reduction was increased with the combination. This combination might be an option against disseminated sporotrichosis, especially when itraconazole or amphotericin B at optimal doses are contraindicated.