Background: Cancer is one of the most common non-communicable diseases in both sexes and a major cause of disability and death around the world, as well as in Iran. The aim of the present manuscript is to report the results of the Global Burden of Disease study 2010 (the GBD 2010) to compare them with other similar findings. The paper also discusses the current deficiencies in the GBD study. Our aim was to describe and criticize the attributed burden of cancers according to the GBD results by sex and age. Methods: The GBD 2010 has profited from 100 collaborators worldwide and provides a vast network of data on health outcomes, vital registries, and population surveys. The GBD has used various scientific-approved methods to estimate important health statuses like death rates, life expectancy, and healthy adjusted life expectancy, disability-adjusted life years, years of living lost due to premature death and years of life with disabilities. In the present study, we extracted and graphed the GBD results for Iran in order to present a better scheme for readers. Results: The mortality rate of cancers in Iranians has increased by about 8.5%, while the disability-adjusted life year rates have declined by about 9%, and years lost due to premature death have also decreased by about 10% from 1990 to 2010 compared to an 85% increase in years of life with disabilities in the same time period. Conclusion: The burden of all non-communicable diseases (NCDs) including cancers shows a decrease during the past two decades. However, these diseases still remain a global health challenge. Prevention should be considered as an important priority and responsibility. The health authorities also need to determine the burden of cancers at national and sub-national levels for implementation of effective preventive strategies. © 2015 Academy of Medical Sciences of I.R. Iran. All rights reserved.