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American Chemical Society, Journal of Natural Products, 11(78), p. 2537-2544, 2015

DOI: 10.1021/acs.jnatprod.5b00457

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Curare Alkaloids: Constituents of a Matis Dart Poison

Journal article published in 2015 by Zalo R. Malca Garcia, Gonzalo R. Malca Garcia, Lothar Hennig, Irina V. Shelukhina, Denis S. Kudryavtsev, Rainer W. Bussmann ORCID, Victor I. Tsetlin, Athanassios Giannis
This paper is available in a repository.
This paper is available in a repository.

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Abstract

A phytochemical study of dart and arrow poison from the Matis tribe led to the identification of D-(−)-quinic acid, L-malic acid, ethyldimethylamine, magnoflorine, and five new bisbenzyltetrahydroisoquinoline alkaloids (BBIQAs), 1−5. d-Tubocurarine could not be identified among these products. BBIQA (3) contains a unique linkage at C-8 and C-11′. All structures were characterized by a combination of NMR and HRESIMS data. The effects of Matis poison and individual BBIQAs (1−3) on rat muscle nAChR expressed in Xenopus oocytes have been investigated using the two-electrode voltage clamp technique.