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National Academy of Sciences, Proceedings of the National Academy of Sciences, 5(104), p. 1599-1603, 2007

DOI: 10.1073/pnas.0508830104

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Estimation of the rate of killing by cytotoxic T lymphocytesin vivo

Journal article published in 2007 by Roland R. Regoes, Daniel L. Barber ORCID, Rafi Ahmed, Rustom Antia
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Cytotoxic T lymphocytes (CTL) help control virus infections by killing virus-infected (target) cells. How fast do CTL find and kill target cells in vivo ? Experiments allow us to follow populations of labeled target cells after their transfer into immune mice where they are killed by CTL. Here, we develop models of the migration and killing processes involved in these experiments and use them to quantitatively analyze the in vivo killing data. These models allow us to estimate the rate constant for killing of target cells by CTL.