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Wiley, British Journal of Clinical Pharmacology, 5(76), p. 827-828, 2013

DOI: 10.1111/bcp.12175

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Network meta-analysis and the comparison of efficacy and tolerability of anti-epileptic drugs for treatment of refractory focal epilepsy

Journal article published in 2013 by Gaetano Zaccara, Sanjay M. Sisodiya, Fabio Giovannelli, Matthew C. Walker ORCID, Dominic C. Heaney, Heather Angus-Leppan, Tim Wehner, Sofia H. Eriksson, Rebecca Liu, Fergus Rugg-Gunn, Simon D. Shorvon, Josemir W. Sander
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

We read with interest the recent paper on network meta-analysis (1) in which efficacy and tolerability of selected antiepileptic drugs in people with refractory focal epilepsy were compared. Whilst network meta-analysis may be a powerful tool, the validity of the results must depend on the selection of studies included. In this respect, we are curious about several methodological points. The authors include some studies, but not others that are of the same nature; the authors deem as appropriate doses that most experienced epilepsy clinicians would consider unusual; and the results that emerge would be considered misleading by most experienced epilepsy clinicians.