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Elsevier, Journal of Molecular Biology, 5(410), p. 875-886, 2011

DOI: 10.1016/j.jmb.2011.03.005

Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, Biopolymers and Cell, 5(27), p. 381-382

DOI: 10.7124/bc.000128

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Association of mitochondrial lysyl-tRNA synthetase with HIV-1 GagPol involves catalytic domain of the synthetase and transframe and integrase domains of Pol

Journal article published in 2011 by Lydia Kobbi, José Dias ORCID, Guillaume Octobre, V. F. Shalak, Martine Comisso, M. Kaminska, Marc Mirande
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Aim. Analyze the interaction between Lysyl-tRNA synthetase (LysRS) and HIV-1 GagPol to know whether a particular N-terminal sequence of mitochondrial LysRS triggers a specific recognition with GagPol. Methods. Yeast two-hybrid analysis, immunoprecipitation. Results. We have shown that LysRS associates with the Pol domain of GagPol. Conclusions. A model of the assembly of the LysRS:tRNA3Lys:GagPol packaging complex is proposed.