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BioMed Central, Particle and Fibre Toxicology, 1(9), p. 30

DOI: 10.1186/1743-8977-9-30

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Experimental determination of the respiratory tract deposition of diesel combustion particles in patients with chronic obstructive pulmonary disease

Journal article published in 2012 by Jakob Löndahl, Erik Swietlicki, Jenny Rissler ORCID, Agneta Bengtsson, Christoffer Boman, Anders Blomberg, Thomas Sandström
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract Background Air pollution, mainly from combustion, is one of the leading global health risk factors. A susceptible group is the more than 200 million people worldwide suffering from chronic obstructive pulmonary disease (COPD). There are few data on lung deposition of airborne particles in patients with COPD and none for combustion particles. Objectives To determine respiratory tract deposition of diesel combustion particles in patients with COPD during spontaneous breathing. Methods Ten COPD patients and seven healthy subjects inhaled diesel exhaust particles generated during idling and transient driving in an exposure chamber. The respiratory tract deposition of the particles was measured in the size range 10–500 nm during spontaneous breathing. Results The deposited dose rate increased with increasing severity of the disease. However, the deposition probability of the ultrafine combustion particles (