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Wiley, British Journal of Haematology, 5(126), p. 722-725, 2004

DOI: 10.1111/j.1365-2141.2004.05093.x

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Clearance of coagulation factor VIII in very low-density lipoprotein receptor knockout mice

Journal article published in 2004 by Niels Bovenschen, Ko Willems van Dijk, Ko Willems Dijk ORCID, Louis M. Havekes, Koen Mertens, Bart J. M. van Vlijmen, Bart J. M. Vlijmen
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Low-density lipoprotein receptor-related protein (LRP) contributes to factor VIII (FVIII) catabolism in vivo. Besides LRP, FVIII also interacts with very low-density lipoprotein receptor (VLDLR) in vitro. We investigated the physiological role of VLDLR in FVIII catabolism, using knockout mouse models for VLDLR and LRP, alone and in combination. VLDLR(-/-) mice displayed normal plasma FVIII, whereas VLDLR(-/-) LRP(-) double-knockout mice had slightly increased FVIII compared with LRP-deficient mice. Remarkably, VLDLR deficiency slightly accelerated FVIII clearance. Adenovirus-mediated overexpression of VLDLR did not lower plasma FVIII in LRP-deficient mice. We conclude that VLDLR does not act in concert with LRP in FVIII clearance in vivo.