Published in

Elsevier, Phytochemistry, 11-12(71), p. 1381-1386

DOI: 10.1016/j.phytochem.2010.05.014

Links

Tools

Export citation

Search in Google Scholar

Cembranolides from the stem bark of the Southern African medicinal plant Croton gratissimus (Euphorbiaceae)

Journal article published in 2010 by Dulcie A. Mulholland, Moses K. Langat, Neil R. Crouch, Helen M. Coley, Emily M. Mutambi, Jean-Marc Nuzillard ORCID
This paper is available in a repository.
This paper is available in a repository.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Red circle
Postprint: archiving forbidden
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

The stem bark of Croton gratissimus (Euphorbiaceae) yielded four cembranolides, including the first reported example of a 2,12-cyclocembranolide, (+)-[1R*,2S*,7S*,8S*,12R*]-7,8-epoxy-2,12-cyclocembra-3E,10Z-dien-20,10-olide, whose structure was confirmed by means of single crystal X-ray analysis. This compound showed moderate activity against the PEO1 and PEO1TaxR ovarian cancer cell lines.