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Cell Press, Chemistry and Biology, 9(18), p. 1067-1068, 2011

DOI: 10.1016/j.chembiol.2011.09.004

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Bypassing GPCRs with Chemical Dimerizers

Journal article published in 2011 by J. Goedhart ORCID, T. W. J. Gadella ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

G protein-coupled receptors (GPCRs) activate heterotrimeric G protein complexes. In this issue, Putyrski and Schultz (2011) describe a rapamycin-based system to bypass the GPCR by direct activation of a specific heterotrimeric G protein subunit, which induces downstream signaling cascades.