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American Chemical Society, Journal of the American Chemical Society, 41(126), p. 13190-13191, 2004

DOI: 10.1021/ja0462777

Wiley-VCH Verlag, ChemInform, 6(36), 2005

DOI: 10.1002/chin.200506053

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Radical Deoxygenation of Hydroxyl Groups via Phosphites

Journal article published in 2004 by Liming Zhang ORCID, Masato Koreeda
This paper is available in a repository.
This paper is available in a repository.

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Abstract

A highly efficient, two-step sequence method for the deoxygenation of hydroxyl groups has been developed. The method involves the preparation of the 2-(2-iodophenyl)ethyl methyl phosphite derivative of an alcohol using methyl dichlorophosphite and 2-(2-iodophenyl)ethanol. Treatment of the phosphite intermediate with (n-Bu)3SnH/AIBN in refluxing benzene cleanly produces the deoxygenation product of the original alcohol.