Published in
Cell Press, Cancer Cell, 6(21), p. 715-716, 2012
DOI: 10.1016/j.ccr.2012.05.029
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Silencing the Killers: Paracrine Immune Suppression in Pancreatic Cancer
Journal article published in 2012 by
Adrienne D. Cox 
,
Kenneth P. Olive
,
Kenneth P. Olive
This paper was not found in any repository, but could be made available legally by the author.
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Abstract
Pancreatic cancers are characterized by high levels of inflammatory cells and profound immune suppression. In this issue of Cancer Cell, Bayne et al. and Pylayeva-Gupta et al. show that KRAS-driven, tumor cell-secreted GM-CSF recruits myeloid-derived suppressor cells to the stroma to abrogate tumor cell immune clearance by killer T lymphocytes.