Published in
Cambridge University Press, British Journal of Psychiatry, 3(209), p. 236-243, 2016
DOI: 10.1192/bjp.bp.115.168229
Links
- ORCID
- Cambridge University Press
- ORCID
- ORCID
- [hdl.handle.net]
- [sro.sussex.ac.uk] | PDF
- [www.researchgate.net] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [centaur.reading.ac.uk] | PDF
- [sro.sussex.ac.uk] | PDF
- [kclpure.kcl.ac.uk] | PDF
- [ueaeprints.uea.ac.uk] | PDF
Tools
Genome-wide association study of response to cognitive behavioural therapy in children with anxiety disorders
,
S. Bo gels,
Charles Curtis,
Kristian Arendt,
Susan Bögels,
Peter Cooper,
Cathy Creswell,
Tim Dalgleish ,
Catharina A. Hartman,
K. Ho tzel,
Einar R. Heiervang,
Katrin Hötzel
and other authors.
Full text: Download
Abstract
BackgroundAnxiety disorders are common, and cognitive–behavioural therapy (CBT) is a first-line treatment. Candidate gene studies have suggested a genetic basis to treatment response, but findings have been inconsistent.AimsTo perform the first genome-wide association study (GWAS) of psychological treatment response in children with anxiety disorders (n = 980).MethodPresence and severity of anxiety was assessed using semi-structured interview at baseline, on completion of treatment (post-treatment), and 3 to 12 months after treatment completion (follow-up). DNA was genotyped using the Illumina Human Core Exome-12v1.0 array. Linear mixed models were used to test associations between genetic variants and response (change in symptom severity) immediately post-treatment and at 6-month follow-up.ResultsNo variants passed a genome-wide significance threshold (P=5×10–8) in either analysis. Four variants met criteria for suggestive significance (P<5×10–6) in association with response post-treatment, and three variants in the 6-month follow-up analysis.ConclusionsThis is the first genome-wide therapygenetic study. It suggests no common variants of very high effect underlie response to CBT. Future investigations should maximise power to detect single-variant and polygenic effects by using larger, more homogeneous cohorts.