Inflammatory Bowel disease (IBD), such as Crohn's and Ulcerative Colitis, are pathologies characterized by a chronic inflammation of the gastrointestinal tract. Their etiopathogenesis is not yet fully understood. immune system and heat shock proteins (HSPS) dysfunctions are considered to be among the most likely causes of these diseases. Butyrate is a short-chain fatti acid mainly produced by intestinal microflora. it has a trophic, beneficial and protective role in the colonic mucosa, and it also induces changes in Hsp levels and localizations. The administration of specific probiotic formulations in order to increase the production of butyirate is a novel therapeutic supplement in the recent years. the current findings need of butyirate in the colonocytes of IBD patients.