Distribution across bacterial genomes of coding sequences for 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase (hmgr), the key enzyme of the classical mevalonate pathway; and for HMB-PP synthase (ispG) and HMB-PP reductase (ispH), two enzymes of the alternative non-mevalonate pathway of isoprenoid synthesis. Genomic and protein sequences from bacterial species of relevance for the present study were retrieved from the public servers at the National Center for Biotechnology Information (http://www.ncbi.nlm.nih.gov), Wellcome Trust Sanger Centre (http://www.sanger.ac.uk), Washington University Genome Sequencing Center (http://genome.wustl.edu), and Baylor College of Medicine Human Genome Sequencing Center (http://www.hgsc.bcm.tmc.edu). Sequence homologies were analyzed by TBLASTN searches, using the corresponding sequences from E. coli, Listeria monocytogenes, and Staphylococcus aureus as templates. (0.03 MB PDF)