Encapsulation of Water-Insoluble Drugs in Polymer Capsules Prepared Using Mesoporous Silica Templates for Intracellular Drug Delivery
Journal article published in 2010 by
Yajun Wang,
Yan Yan 
,
Jiwei Cui,
Leticia Hosta-Rigau,
Joan K. Heath,
Edouard C. Nice,
Frank Caruso
,
Jiwei Cui,
Leticia Hosta-Rigau,
Joan K. Heath,
Edouard C. Nice,
Frank Caruso
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Abstract
Water-insoluble compounds were encapsulated in polymer capsules through mesoporous silica nanoparticle-mediated layer-by-layer assembly. The drug-loaded capsules exhibit excellent colloidal stability and high potency to colorectal cancer cells in vitro with similar cytotoxicity to the free drug dissolved in organic solvent.