Wiley, Angewandte Chemie International Edition, 38(49), p. 6795-6797, 2010
Wiley, Angewandte Chemie, 38(122), p. 6947-6949, 2010
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(Figure Presented) Doing double duty: A metalloproteinase inhibitor that can be activated by reactive oxygen species (ROS) has been designed to protect the blood-brain barrier (BBB) in ischemic reperfusion injury. By both neu-tralizing damaging ROS and inhibiting degradative metalloproteinases, a single compound can eliminate both threats to the BBB upon activation.