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Wiley, Angewandte Chemie International Edition, 38(49), p. 6795-6797, 2010

DOI: 10.1002/anie.201003819

Wiley, Angewandte Chemie, 38(122), p. 6947-6949, 2010

DOI: 10.1002/ange.201003819

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Hydrogen Peroxide Activated Matrix Metalloproteinase Inhibitors: A Prodrug Approach**

Journal article published in 2010 by Jody L. Major Jourden, Seth M. Cohen ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

(Figure Presented) Doing double duty: A metalloproteinase inhibitor that can be activated by reactive oxygen species (ROS) has been designed to protect the blood-brain barrier (BBB) in ischemic reperfusion injury. By both neu-tralizing damaging ROS and inhibiting degradative metalloproteinases, a single compound can eliminate both threats to the BBB upon activation.