Structure Casts Light on mtDNA Replication
Journal article published in 2009 by
Maria Falkenberg,
Nils-Göran Larsson 
This paper is made freely available by the publisher.
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Abstract
In this issue, Lee et al. (2009) present a crystal structure of the human mitochondrial DNA polymerase (POLgamma). The structure of this heterotrimeric enzyme lays a foundation for understanding how POLgamma mutations cause human mitochondrial disease and why some antiviral nucleoside analogs cause cellular toxicity.