Published in
American Chemical Society, Organic Letters, 8(9), p. 1525-1528, 2007
DOI: 10.1021/ol070294u
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Thalassospiramides A and B, Immunosuppressive Peptides from the Marine BacteriumThalassospirasp.
Journal article published in 2007 by
Dong-Chan Oh,
Wendy K. Strangman,
Christopher A. Kauffman,
Paul R. Jensen,
William Fenical 
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Abstract
[structure: see text] Two new cyclic peptides, thalassospiramides A and B (1 and 2), were isolated from a new member of the marine alpha-proteobacterium Thalassospira. The thalassospiramides, the structures of which were assigned by combined spectral and chemical methods, bear unusual gamma-amino acids and show immunosuppressive activity in an interleukin-5 production inhibition assay (IC50 = 5 muM for thalassospiramide B).