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Elsevier, Mechanisms of Ageing and Development, 16(122), p. 2005-2011

DOI: 10.1016/s0047-6374(01)00304-9

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Cerebrospinal fluid τ and β-amyloid(1-42) in dementia disorders

Journal article published in 2001 by Eugeen Vanmechelen ORCID, Hugo Vanderstichele, Frank Hulstaert, Niels Andreasen, Lennart Minthon, Bengt Winblad, Pia Davidsson, Kaj Blennow
This paper is available in a repository.
This paper is available in a repository.

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Abstract

The reliability of cerebrospinal fluid (CSF)-tau and CSF-beta-amyloid assays for diagnosis of Alzheimer's disease and other dementing disorders such as frontotemporal dementia (FTD), dementia with Lewy bodies (DLB) and Creutzfeldt-Jakob disease (CJD) is reviewed. CSF assessment of the two proteins is useful in early diagnosis of AD and to differentiate it from FTD and DLB. Extremely high CSF-tau levels can discriminate CJD from AD.