Published in

Nature Research, Nature, 7527(515), p. 355-364, 2014

DOI: 10.1038/nature13992

Links

Tools

Export citation

Search in Google Scholar

A Comparative Encyclopedia of DNA Elements in the Mouse Genome

Journal article published in 2014 by Beatriz Lacerda de Sousa, Zhihai, Chris Zaleski, Miaohua Zhang, Xiao-Qiao Zhou, Sheng Zhong, Zhihai Ma, Z. Ma, Robert E. Thurman, Feng Yue, Thurman Re, Yin Shen, Dmitri D. Pervouchine, Rajinder Kaul, R. E. Thurman and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Orange circle
Postprint: archiving restricted
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

The laboratory mouse shares the majority of its protein-coding genes with humans, making it the premier model organism in biomedical research, yet the two mammals differ in significant ways. To gain greater insights into both shared and species-specific transcriptional and cellular regulatory programs in the mouse, the Mouse ENCODE Consortium has mapped transcription, DNase I hypersensitivity, transcription factor binding, chromatin modifications and replication domains throughout the mouse genome in diverse cell and tissue types. By comparing with the human genome, we not only confirm substantial conservation in the newly annotated potential functional sequences, but also find a large degree of divergence of sequences involved in transcriptional regulation, chromatin state and higher order chromatin organization. Our results illuminate the wide range of evolutionary forces acting on genes and their regulatory regions, and provide a general resource for research into mammalian biology and mechanisms of human diseases.