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Association for Research in Vision and Ophthalmology, Investigative Ophthalmology & Visual Science, 12(55), p. 8067-8076

DOI: 10.1167/iovs.14-14722

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Shear Stress-Triggered Nitric Oxide Release From Schlemm's Canal Cells

Journal article published in 2014 by Nicole E. Ashpole, Darryl R. Overby ORCID, C. Ross Ethier, W. Daniel Stamer
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Physiological levels of shear stress elicit the release of nitric oxide from human Schlemm's canal cell monolayers. Results suggest a role for nitric oxide signaling in the regulation of conventional outflow resistance during intraocular pressure–induced narrowing of the Schlemm's canal.