This study performed a quantitative validation on a recently developed pressure sensitive transducer system, the F-Scan sensor system. The results indicate that the sensor is adequate for determination of pressure distribution under contact conditions with soft materials. The linear response of the sensor was up to 1.7 MPa with good homogeneity throughout sensor cells. However, the sensor is sensitive to surface conditions, loading speeds, and temperature. Variations also exist from sensor to sensor. In order to have accurate measurement, calibration was recommended in actual clinical or experimental conditions prior to use, including surface contact conditions, loading speeds, and temperature environment. In addition, this sensor system is not suitable for hard surface contact such as plexiglas.