Nanomaterials serve as promising candidates for strain sensing due to unique electromechanical properties by appropriately assembling and tailoring their configurations. Through the crisscross interlacing of graphene micro-ribbons in an over-and-under fashion, the obtained graphene woven fabric (GWF) indicates a good trade-off between the sensitivity and stretchability compared with those in previous studies. In this work, the function of woven fabrics for highly sensitive strain sensing is investigated although network configuration is always a strategy to retain resistance stability. The experimental and simulation results indicate that the ultrahigh mechano-sensitivity with gauge factors of 500 under 2% strain is attributed to the macro woven-fabric geometrical conformation of graphene which induces a large interfacial resistance between the interlaced ribbons and a formation of microscale controllable, locally oriented zigzag cracks near the crossover location, both of which have synergistic effect on improving sensitivity. Meanwhile, the stretchability of GWF could be tailored to as high as over 40% strain by adjusting graphene growth parameters and adopting oblique angle direction stretching simultaneously. We also demonstrate that sensors based on GWFs are applicable to human motion detection, sound signal acquisition and spatially resolved monitoring of external stress distribution.