Genome-wide association studies (GWAS) have identified multiple common genetic variants associated with an increased risk of prostate cancer (PrCa), but these explain less than one-third of the heritability. To identify further susceptibility alleles, we conducted a meta-analysis of four GWAS including 5953 cases of aggressive PrCa and 11 463 controls (men without PrCa). We computed association tests for approximately 2.6 million SNPs and followed up the most significant SNPs by genotyping 49 121 samples in 29 studies through the international PRACTICAL and BPC3 consortia. We not only confirmed the association of a PrCa susceptibility locus, rs11672691 on chromosome 19, but also showed an association with aggressive PrCa [odds ratio = 1.12 (95% confidence interval 1.03-1.21), P = 1.4 x 10(-8)]. This report describes a genetic variant which is associated with aggressive PrCa, which is a type of PrCa associated with a poorer prognosis. ; Amin Al Olama, Ali Kote-Jarai, Zsofia Schumacher, Fredrick R Wiklund, Fredrik Berndt, Sonja I Benlloch, Sara Giles, Graham G Severi, Gianluca Neal, David E Hamdy, Freddie C Donovan, Jenny L Hunter, David J Henderson, Brian E Thun, Michael J Gaziano, Michael Giovannucci, Edward L Siddiq, Afshan Travis, Ruth C Cox, David G Canzian, Federico Riboli, Elio Key, Timothy J Andriole, Gerald Albanes, Demetrius Hayes, Richard B Schleutker, Johanna Auvinen, Anssi Tammela, Teuvo L J Weischer, Maren Stanford, Janet L Ostrander, Elaine A Cybulski, Cezary Lubinski, Jan Thibodeau, Stephen N Schaid, Daniel J Sorensen, Karina D Batra, Jyotsna Clements, Judith A Chambers, Suzanne Aitken, Joanne Gardiner, Robert A Maier, Christiane Vogel, Walther Dork, Thilo Brenner, Hermann Habuchi, Tomonori Ingles, Sue John, Esther M Dickinson, Joanne L Cannon-Albright, Lisa Teixeira, Manuel R Kaneva, Radka Zhang, Hong-Wei Lu, Yong-Jie Park, Jong Y Cooney, Kathleen A Muir, Kenneth R Leongamornlert, Daniel A Saunders, Edward Tymrakiewicz, Malgorzata Mahmud, Nadiya Guy, Michelle Govindasami, Koveela O'Brien, Lynne T Wilkinson, Rosemary A Hall, Amanda L Sawyer, Emma J Dadaev, Tokhir Morrison, Jonathan Dearnaley, David P Horwich, Alan Huddart, Robert A Khoo, Vincent S Parker, Christopher C Van As, Nicholas Woodhouse, Christopher J Thompson, Alan Dudderidge, Tim Ogden, Chris Cooper, Colin S Lophatonanon, Artitaya Southey, Melissa C Hopper, John L English, Dallas Virtamo, Jarmo Le Marchand, Loic Campa, Daniele Kaaks, Rudolf Lindstrom, Sara Diver, W Ryan Gapstur, Susan Yeager, Meredith Cox, Angela Stern, Mariana C Corral, Roman Aly, Markus Isaacs, William Adolfsson, Jan Xu, Jianfeng Zheng, S Lilly Wahlfors, Tiina Taari, Kimmo Kujala, Paula Klarskov, Peter Nordestgaard, Borge G Roder, M Andreas Frikke-Schmidt, Ruth Bojesen, Stig E Fitzgerald, Liesel M Kolb, Suzanne Kwon, Erika M Karyadi, Danielle M Orntoft, Torben Falck Borre, Michael Rinckleb, Antje Luedeke, Manuel Herkommer, Kathleen Meyer, Andreas Serth, Jurgen Marthick, James R Patterson, Briony Wokolorczyk, Dominika Spurdle, Amanda Lose, Felicity McDonnell, Shannon K Joshi, Amit D Shahabi, Ahva Pinto, Pedro Santos, Joana Ray, Ana Sellers, Thomas A Lin, Hui-Yi Stephenson, Robert A Teerlink, Craig Muller, Heiko Rothenbacher, Dietrich Tsuchiya, Norihiko Narita, Shintaro Cao, Guang-Wen Slavov, Chavdar Mitev, Vanio The UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology The UK ProtecT Study Collaborators The Australian Prostate Cancer Bioresource The PRACTICAL Consortium Chanock, Stephen Gronberg, Henrik Haiman, Christopher A Kraft, Peter Easton, Douglas F Eeles, Rosalind A Human molecular genetics Hum Mol Genet. 2012 Nov 2.