Published in

Wiley, FEBS Letters, 2(415), p. 134-138, 1997

DOI: 10.1016/s0014-5793(97)01103-4

Links

Tools

Export citation

Search in Google Scholar

Leptin interacts with glucagon-like peptide-1 neurons to reduce food intake and body weight in rodents

Journal article published in 1997 by Anthony P. Goldstone ORCID, Julian G. Mercer, Irene Gunn, Kim M. Moar, C. Mark B. Edwards, C. Mark B. Edwards, Michela Rossi, Jane K. Howard, Shahnawaz Rasheed, Mandy D. Turton, Caroline Small, Melanie M. Heath, Donal O'Shea, Joanna Steere, Karim Meeran and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Orange circle
Postprint: archiving restricted
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

The adipose tissue hormone, leptin, and the neuropeptide glucagon-like peptide-1 (7-36) amide (GLP-1) both reduce food intake and body weight in rodents. Using dual in situ hybridization, long isoform leptin receptor (OB-Rb) was localized to GLP-1 neurons originating in the nucleus of the solitary tract. ICV injection of the specific GLP-1 receptor antagonist, exendin(9-39), at the onset of dark phase, did not affect feeding in saline pre-treated controls, but blocked the reduction in food intake and body weight of leptin pre-treated rats. These findings suggest that GLP-1 neurons are a potential target for leptin in its control of feeding.