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Elsevier, Biochemical and Biophysical Research Communications, 3(152), p. 951-956

DOI: 10.1016/s0006-291x(88)80375-9

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Depletion of protein kinase C induced by an anti HLA class I monoclonal antibody in phytohemagglutinin activated human T cells

Journal article published in 1988 by Licia Poltronieri, Edon Melloni, Michele Rubini ORCID, Rita Selvatici ORCID, Cristina Mazzilli, Roberto Baricordi, Enrico Gandini
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Anti HLA Class I Monoclonal Antibody depletes Protein Kinase C (PKC) to 20% of control value in PHA activated human T cells. The effect is reversible: in 24 hours the enzymatic activity returns to 58% of control value. Removal of antibody from the culture medium increases the rate of recovery. Implications of this finding for the modulation by HLA Class I antigens of the proliferative response of T cells to lectins are discussed.