Dissemin is shutting down on January 1st, 2025

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Elsevier, Chest Journal

DOI: 10.1016/j.chest.2015.12.018

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Reduced Antiviral Interferon Production in Poorly Controlled Asthma Is Associated With Neutrophilic Inflammation and High-Dose Inhaled Corticosteroids

Journal article published in 2016 by Jodie L. Simpson, Melanie Carroll, Ian A. Yang ORCID, Paul N. Reynolds, Sandra Hodge, Alan L. James, Peter G. Gibson, John W. Upham
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Asthma is a heterogeneous chronic inflammatory disease where host defence against respiratory viruses such as human rhinovirus (HRV) may be abnormal. This is a matter of some controversy, with some investigators reporting reduced type I interferon (IFN) synthesis while others suggest that type I IFN synthesis is relatively normal in asthma.