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Elsevier, Bioorganic and Medicinal Chemistry, 14(21), p. 4378-4387, 2013

DOI: 10.1016/j.bmc.2013.04.075

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The synthesis of neurotensin antagonist SR 48692 for prostate cancer research

Journal article published in 2013 by I. R. Baxendale, S. Cheung, M. O. Kitching ORCID, S. V. Ley, J. W. Shearman
This paper is available in a repository.
This paper is available in a repository.

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Abstract

An improved synthesis of the molecule SR 48692 is presented and its use as a neurotensin antagonist biological probe for use in cancer research is described. The preparation includes an number of enhanced chemical conversions and strategies to overcome some of the limiting synthetic transformations in the original chemical route.