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Elsevier, Molecular Genetics and Metabolism, 3(105), p. 525-527

DOI: 10.1016/j.ymgme.2011.12.020

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Association between a common KCNJ11 polymorphism (rs5219) and new-onset posttransplant diabetes in patients treated with Tacrolimus

Journal article published in 2012 by Beatriz Tavira ORCID, Eliecer Coto, Armando Torres, Carmen Díaz-Corte, Beatriz Díaz-Molina, Francisco Ortega, Manuel Arias, Juan M. Díaz, Rafael Selgas, Carlos López-Larrea, Marta Ruiz-Ortega, Alberto Ortiz, Elena González ORCID, Josep M. Campistol, Victoria Alvarez ORCID
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Abstract

KCNJ11 polymorphisms have been linked to the risk of developing type 2 diabetes. Our aim was to define the contribution of KCNJ11 to new-onset diabetes after transplantation (NODAT) among patients treated with Tacrolimus (Tac). A total of 115 NODAT and 205 non-NODAT were genotyped for rs5219 (p.E23K). AA + AG genotypes were significantly associated with NODAT-risk (p = 0.004; OR = 2.10). The reported effect of this KCNJ11 polymorphism on insulin release by beta cells could explain this association.