Published in
BMJ Publishing Group, BMJ, dec29 1(341), p. c6760-c6760, 2010
DOI: 10.1136/bmj.c6760
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Longlasting insecticidal nets for prevention of Leishmania donovani infection in India and Nepal: paired cluster randomised trial
,
Elisabeth Wreford Andersen,
Shri Prakash Singh,
Suman Rijal,
Shyam Sundar,
Bart Ostyn,
François Chappuis,
Surendra Uranw,
Kamlesh Gidwani,
Basudha Khanal,
Madhukar Rai,
Ishwari Sharma Paudel,
Murari Lal Das,
Rajiv Kumar,
Pankaj Srivastava
and other authors.
Full text: Download
Abstract
Objective: To test the effectiveness of large scale distribution of longlasting nets treated with insecticide in reducing the incidence of visceral leishmaniasis in India and Nepal. Design: Paired cluster randomised controlled trial designed to detect a 50% reduction in incidence of Leishmania donovani infection. Setting: Villages in Muzaffarpur district in India and Saptari, Sunsari, and Morang districts in Nepal. Participants: 13 intervention and 13 control clusters. 12 691 people were included in the analysis of the main outcome (infection), and 19 810 were enrolled for the secondary (disease) end point. Intervention: Longlasting insecticidal nets (treated with deltamethrin) were distributed in the intervention clusters in December 2006. Main outcome measures: Infection was determined by direct agglutination test at 12 and 24 months after the intervention in those who had negative results (titre