The dispersal of Homo sapiens out of Africa has been extensively researched across several disciplines. Here we review the evidence for spatial and temporal variability in lithic (stone tool) technologies relative to the predictions of two major hypotheses: 1) that a single successful dispersal occurred 60–50 thousand years ago (ka), marked by a trail of geometric/microlithic technologies, and 2) that multiple dispersals occurred, beginning much earlier (probably in Marine Isotope Stage [MIS] 5), associated with Middle Palaeolithic technology in its early phase. Our results show that Late Pleistocene geometric/microlithic technologies exhibit significant temporal and regional differences between each other. These differences suggest independent, convergent origins for these technologies, which are likely to have been repeatedly re-invented. In contrast, we identify similarities between East African lithic technologies from MIS 8 onwards and Middle Palaeolithic assemblages as far east as India by MIS 5. That this constellation of technological features – particularly an emphasis on centripetal Levallois reduction reflecting interchangeable preferential and recurrent methods, along with particular retouched forms such as points – transcends ecologies and raw material types suggests that it is unlikely to entirely reflect technological convergence (analogy). Our results indicate an early onset of multiple dispersals out of Africa. The hypothesis of an early onset to successful dispersal is entirely consistent with the possibility of further subsequent (post-MIS 5) dispersals out of Africa. Testing such hypotheses through quantified comparative lithic studies and interdisciplinary research is therefore likely to significantly advance understanding of the earliest H. sapiens dispersals.