Wiley, FEBS Letters, 1(513), p. 77-84, 2002
DOI: 10.1016/s0014-5793(01)03308-7
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The FYVE zinc finger domain is conserved from yeast (five proteins) to man (27 proteins). It functions in the membrane recruitment of cytosolic proteins by binding to phosphatidylinositol 3-phosphate (PI3P), which is found mainly on endosomes. Here we review recent work that sheds light on the targeting of FYVE finger proteins to PI3P-containing membranes, and how these proteins serve to regulate multiple cellular functions. © 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.