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Faculdade de Medicina / USP, Clinics, 7(70), p. 515-523, 2015

DOI: 10.6061/clinics/2015(07)09

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Cytomegalovirus infection in transplant recipients

Journal article published in 2015 by Luiz Sergio Azevedo, Luiz Sergio Azevedo*, Lígia Camera Pierrotti, Edson Abdala ORCID, Silvia Figueiredo Costa ORCID, Tânia Mara Varejão Strabelli, Silvia Vidal Campos, Jéssica Fernandes Ramos, Acram Zahredine Abdul Latif, Nadia Litvinov, Natalya Zaidan Maluf, Hh Caiaffa Filho ORCID, Helio Hehl Caiaffa Filho, Claudio Sergio Pannuti, Marta Heloisa Lopes ORCID and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Cytomegalovirus infection is a frequent complication after transplantation. This infection occurs due to transmission from the transplanted organ, due to reactivation of latent infection, or after a primary infection in seronegative patients and can be defined as follows: latent infection, active infection, viral syndrome or invasive disease. This condition occurs mainly between 30 and 90 days after transplantation. In hematopoietic stem cell transplantation in particular, infection usually occurs within the first 30 days after transplantation and in the presence of graft-versus-host disease. The major risk factors are when the recipient is cytomegalovirus seronegative and the donor is seropositive as well as when lymphocyte-depleting antibodies are used.