ollowing the emergence of the Filoviridae family members Marburg virus and Ebola virus nearly five decades ago, there has been great interest in deciphering the molecular events that underlie the severe pathologies associated with infections by these viruses. Although there is significant insight into the patho- logical events that occur following infection gained from both investigations of human patients and from experimental animal infections, there is a relative paucity of information regarding the role of molecular interactions between the host and pathogen during disease progression or resolution. There is now an increasing appreciation that host-mediated phosphorylation of filovirus proteins serves a regu- latory role for filovirus protein function/activity. Here, we discuss the role of these phosphorylation events in the filovirus life cycle