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Elsevier, Applied Radiation and Isotopes, 2(68), p. 297-302

DOI: 10.1016/j.apradiso.2009.10.006

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Full automation of 68Ga labelling of DOTA-peptides including cation exchange prepurification

Journal article published in 2010 by M. Ocak, M. Antretter, R. Knopp, F. Kunkel, M. Petrik ORCID, N. Bergisadi, C. Decristoforo
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Here we describe a fully automated approach for the synthesis of (68)Ga-labelled DOTA-peptides based on pre-concentration and purification of the generator eluate by using a cation exchange-cartridge and its comparison with fully automated direct labelling applying fractionated elution. Pre-concentration of the eluate on a cation exchange cartridge both using a resin-based and a disposable cation-exchange cartridge efficiently removed (68)Ge as well as major metal contaminations with Fe and Zn. This resulted in a high labelling efficiency of DOTA-peptides at high specific activity (SA) with short synthesis times.