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Centers for Disease Control and Prevention, Emerging Infectious Diseases, 8(15), p. 1171-1175, 2009

DOI: 10.3201/eid1508.090015

Centers for Disease Control and Prevention, Emerging Infectious Diseases, 8(15), p. 1171-1175

DOI: 10.3201/eid1508.090051

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Response to Imported Case of Marburg Hemorrhagic Fever, the Netherlands

Journal article published in 2009 by Gerard J. J. van Doornum, Franchette van den Berkmortel, Jaap T. van Dissel, Aura Timen, Marion P. G. Koopmans, Ann C. T. M. Vossen ORCID, G. J. J. Van Doornum, G. J. J. van Doornum, Stephan Günther, F. Van Den Berkmortel, Kees M. Verduin, F. van den Berkmortel, Sabine Dittrich, Petra Emmerich, Albert D. M. E. Osterhaus and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

On July 10, 2008, Marburg hemorrhagic fever was confirmed in a Dutch patient who had vacationed recently in Uganda. Exposure most likely occurred in the Python Cave (Maramagambo Forest), which harbors bat species that elsewhere in Africa have been found positive for Marburg virus. A multidisciplinary response team was convened to perform a structured risk assessment, perform risk classification of contacts, issue guidelines for follow-up, provide information, and monitor the crisis response. In total, 130 contacts were identified (66 classified as high risk and 64 as low risk) and monitored for 21 days after their last possible exposure. The case raised questions specific to international travel, postexposure prophylaxis for Marburg virus, and laboratory testing of contacts with fever. We present lessons learned and results of the follow-up serosurvey of contacts and focus on factors that prevented overreaction during an event with a high public health impact.