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BioMed Central, BMC Research Notes, 1(6), 2013

DOI: 10.1186/1756-0500-6-427

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Is ABCC6 a genuine mitochondrial protein?

Journal article published in 2013 by Marc Ferré ORCID, Pascal Reynier ORCID, Arnaud Chevrollier, Delphine Prunier-Mirebeau, Georges Lefthériotis, Daniel Henrion, Dominique Bonneau, Vincent Procaccio ORCID, Ludovic Martin
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract Background A recent article in Circulation Research suggests that the protein ABCC6, which when defective is responsible for pseudoxanthoma elasticum, an inherited condition with skin, eye and cardiovascular manifestations, is associated with dysfunction in mitochondria – Martin et al.: ABCC6 Localizes to the Mitochondria-Associated Membrane . Circ Res 2012, 111: 516 – 520. We present complementary information based on a bioinformatics analysis, which was not performed in the article cited, to examine the suggestion that ABCC6 is localized to mitochondria. Results All the computational strategies and integrative approaches that constitute references in the field indicate that ABCC6 is localized outside of mitochondria. Conclusion Our computational and integrative results, including both experimental and predictive data, show that there is no support in favor of the localization of ABCC6 in mitochondria.