Magnetic porous silicon flakes (MPSF) have been obtained from meso porous silicon layers formed by multi-step anodization and a subsequent composite formation with Fe oxide nanoparticles by thermal annealing. The magnetic nanoparticles are adhered to the surface and penetrate inside the pores. Their structure evolves as a result of the annealing treatments as derived from X-ray diffraction and X-ray absorption analyses. Moreover, by tailoring the magnetic load, the dynamic and hydrodynamic properties of the particles are controlled, as observed by the pressure displayed against a sensor probe. Preliminary functionality experiments have been performed by using an eye model, seeking at a potential use of the MPSFs as a reinforcement of restored detached retina. It has been observed that optimal flake immobilization is obtained when the MPSFs reach values of magnetic saturation above 10(-4) A·m(2)/g. Furthermore, the MPSF have demonstrated to be preliminarily biocompatible in vitro. Moreover, New Zealand rabbit in vivo models have demonstrated their short term histocompatibility and their magnetic functionality as retina pressure actuators.