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American Diabetes Association, Diabetes Care, 2(31), p. 361-362, 2008

DOI: 10.2337/dc07-1276

American Diabetes Association, Diabetes Care, 9(31), p. e67-e67, 2008

DOI: 10.2337/dc08-0038

American Diabetes Association, Diabetes Care, 9(31), p. e68-e68, 2008

DOI: 10.2337/dc08-0468

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High Serum Uric Acid as a Novel Risk Factor for Type 2 Diabetes

Journal article published in 2007 by Chia-Yen Dai, Abbas Dehghan ORCID, Mandy van Hoek, Wan-Long Chuang, Chi-Kong Ho, Tsan-Teng Ou, Eric Jg G. Sijbrands, Jee-Fu Huang, Albert Hofman, Ming-Yen Hsieh, Jacqueline Cm M. Witteman, Ming-Lung Yu
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

OBJECTIVE—To investigate the association between serum uric acid level and risk of type 2 diabetes. RESEARCH DESIGN AND METHODS—The population for analysis consisted of 4,536 subjects free from diabetes at baseline. During a mean of 10.1 years of follow-up, 462 subjects developed diabetes. RESULTS—The age- and sex-adjusted hazard ratios (HRs) (95% CIs) for diabetes were 1.30 (0.96–1.76) for the second, 1.63 (1.21–2.19) for the third, and 2.83 (2.13–3.76) for the fourth quartile of serum uric acid, in comparison with the first quartile. After adjustment for BMI, waist circumference, systolic and diastolic blood pressure, and HDL cholesterol, the HRs decreased to 1.08 (0.78–1.49), 1.12 (0.81–1.53), and 1.68 (1.22–2.30), respectively. CONCLUSIONS—The results of this population-based study suggest that serum uric acid is a strong and independent risk factor for diabetes.