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Elsevier, Biochemical Pharmacology, 1(44), p. 177-179, 1992

DOI: 10.1016/0006-2952(92)90053-l

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Inhibition of transketolase and pyruvate decarboxylase by omeprazole

Journal article published in 1992 by Peter F. Nixon, Russell J. Diefenbach ORCID, Ronald G. Duggleby
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Omeprazole inhibited two thiamin diphosphate-dependent enzymes, pyruvate decarboxylase (EC 4.1.1.1, PDC) from Zymomonas mobilis and transketolase (EC 2.2.1.1, TK) from human erythrocytes. Inhibition of PDC was competitive with the coenzyme with a Ki value of 42 +/- 3 microM, whereas inhibition of TK was complex.