Chaos theory has a manifold variety of applications in science and engineering. In this paper, a new chemical chaotic reactor is derived by modifying the chemical chaotic reactor system obtained by the Huang (2005). This paper gives a summary description of the chemical reactor dynamics and the chaos dynamic analysis. Next, new results are obtained for the output regulation of the novel chemical chaotic reactor system. MATLAB plots have been shown to illustrate the phase portraits of the novel chemical chaotic attractor and the output regulation of the novel chemical chaotic reactor system via integral sliding mode control.