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Nature Research, Scientific Reports, 1(6), 2016

DOI: 10.1038/srep18780

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Visualisation of newly synthesised collagen in vitro and in vivo

Journal article published in 2016 by Corien Oostendorp, Peter J. E. Uijtdewilligen, Elly M. Versteeg, Theo G. Hafmans, Ellen H. van den Bogaard, Paul K. J. D. de Jonge ORCID, Ali Pirayesh, Johannes W. Von Den Hoff, Ernst Reichmann, Willeke F. Daamen, Toin H. van Kuppevelt
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

AbstractIdentifying collagen produced de novo by cells in a background of purified collagenous biomaterials poses a major problem in for example the evaluation of tissue-engineered constructs and cell biological studies to tumor dissemination. We have developed a universal strategy to detect and localize newly deposited collagen based on its inherent association with dermatan sulfate. The method is applicable irrespective of host species and collagen source.