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From Gene Regulation to Gene Function: Regulatory Networks inBacillus subtilis

Journal article published in 2002 by Colin R. Harwood ORCID, Ivan Moszer
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Bacillus subtilis is a sporulating Gram-positive bacterium that lives primarily in the soil and associated water sources. The publication of the B. subtilis genome sequence and subsequent systematic functional analysis and gene regulation programmes, together with an extensive understanding of its biochemistry and physiology, makes this micro-organism a prime candidate in which to model regulatory networks in silico. In this paper we discuss combined molecular biological and bioinformatical approaches that are being developed to model this organism's responses to changes in its environment.