Published in
Elsevier, Kidney International, 4(34), p. 507-510, 1988
DOI: 10.1038/ki.1988.210
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Localization of the gene for X-linked Alport's syndrome
Journal article published in 1988 by
Han Brunner,
Cock Schröder,
Cor van Bennekom,
Eric Lambermon 
,
Joep Tuerlings,
Daria Menzel,
Hermann Olbing,
Leo Monnens,
Berend Wieringa,
Hans-Hilger Ropers
,
Joep Tuerlings,
Daria Menzel,
Hermann Olbing,
Leo Monnens,
Berend Wieringa,
Hans-Hilger Ropers
This paper is made freely available by the publisher.
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Abstract
X-chromosomal DNA probes defining various polymorphic DNA markers were used to study genetic linkage in three families with Alport's syndrome. With the DXS17 marker, only a single cross-over was observed in 26 informative meioses, and evidence for linkage was also obtained with the DXS11 marker. These data localize the gene for the X-linked form of Alport's syndrome to the middle of the long arm of the X chromosome.