The purpose of this study was to investigate the acute effects of performing paired-set (PS) versus traditional set (TS) training over three consecutive sets, on volume load and electromyographic fatigue parameters of the latissimus dorsi, biceps brachii, pectoralis major and triceps brachii muscles. Fifteen trained males performed two testing protocols (TS and PS) using 10-repetition maximum loads. The TS protocol consisted of three sets of bench press (BP) followed by three sets of wide-grip seated row (SR). PS consisted of three sets of BP and three sets of SR performed in an alternating manner. Volume load was calculated as load x repetitions. The electromyographic signal, time (CRMS) and frequency (Cf5) domain, parameters were recorded during SR. Under the PS protocol, sets of SR were performed immediately following sets of BP. A two-minute rest interval between the completion of the set of SR and the subsequent set of BP was implemented (e.g.,, between paired sets). Under the TS protocol two-minute rest intervals were implemented between all sets. BP and SR volume loads decreased significantly from set 1 to set 2 and from set 2 to set 3 under both conditions. Volume load was greater for all sets of both exercises under PS as compared to TS. Muscle fatigue indices were greater under PS as compared to TS. In general, these results indicate that as compared to TS, PS produced a greater training volume in less time and may induce greater fatigue and thereby provide an enhanced training stimulus. Copyright (C) 2015 by the National Strength & Conditioning Association.