Dissemin is shutting down on January 1st, 2025

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Public Library of Science, PLoS ONE, 9(10), p. e0138587, 2015

DOI: 10.1371/journal.pone.0138587

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Hypoxia Differentially Regulates Arterial and Venous Smooth Muscle Cell Migration

Journal article published in 2015 by Alice Chanakira, Roderick A. Barke, Devika Kir ORCID, Steve M. Santilli, Sundaram Ramakrishnan, Sabita Roy
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Intimal hyperplasia (IH) is a clinical concern leading to failure of up to 50% of vein grafts and 10% of arterial grafts after 10 years with no known current treatment. Recent studies have shown that hypoxia differentially regulates proliferation of vein derived smooth muscle cells (V-SMC) compared to artery derived smooth muscle cells (A-SMC). The objective of this study is to evaluate the effect of hypoxia on cellular migration and the mechanisms underlying the differential effects of hypoxia on A-SMC and V-SMC migration.